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Development of an anatomically detailed MRI-derived rabbit ventricular model and assessment of its impact on simulations of electrophysiological function

This paper presents a novel methodological pipeline describing the construction and use of high-resolution computational cardiac ventricular models from 25um MR data. Simulations of electrical activation using the model demonstrate how fine-scale anatomical structures (trabeculations, papillary muscles, coronary vasculature), present in such a model for the first time, induce the formation of virtual-electrodes during strong electrical shocks as well as influence the global propagation patterns of electrical activation wavefronts, furthering our understanding of cardiac arrhythmia and defibrillation mechanisms. The finite element model generated in this study was made available for public use with the manuscript, having been downloaded >70 times.