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12 - Aeronautical, Mechanical, Chemical and Manufacturing Engineering
Imperial College London
Characterisation of a soft elastomer poly(glycerol sebacate) designed to match the mechanical properties of myocardial tissue.
Patients at risk of heart failure are often treated using scarce donor transplants. An exploratory approach instead “repairs” the weak section of the heart with a mechanically reinforcing patch that delivers regenerative cells. This paper demonstrates that tailored processing of a particular polymer (PGS) provides a promising solution for “repairing” hearts at risk of failure. This paper was part of the body of work that led to Imperial College €0.388M share of €6.31M for project on elastomeric polymers for cardiac tissue engineering (EU FP-7 214539; 15 partners from 8 EU countries).