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15 - General Engineering

University College London

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Article title

Sealing the skin barrier around transcutaneous implants: in vitro study of keratinocyte proliferation and adhesion in response to surface modifications of titanium alloy.

Type

D - Journal article

DOI

10.1302/0301-620X.90B1.19580

Title of journal

J Bone Joint Surg Br

Article number

Volume number

Issue number

First page of article

114

ISSN of journal

0301-620X

Year of publication

2008

URL

Number of additional authors

Additional information

Modifying titanium surfaces by covalently attached laminin enhances the adhesion of epithelial cells. This is crucial to creating a seal around implants that breach the skin, creating a infection free transcutaneous prosthesis. This is a programme associated with the development of intraosseous transcutaneous amputation prostheses (ITAP) used to treat amputees. ITAP can be applied to amputees of whom there were a total of 4,957 new referrals to prosthetics service centres in England, Northern Ireland, Scotland and Wales. ITAP is in clinical trial in the Royal National Orthopaedic Hospital and a US trial will commence in the United States soon.

Interdisciplinary

Cross-referral requested

Research group

None

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract