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Rapid Magnetic Cell Delivery for Large Tubular Bioengineered Constructs

A multidisciplinary approach using magnetic fields to provide rapid, uniform delivery of cells onto large hollow tissue constructs is described. The technique was optimized with synthetic tubular constructs and validated using cadaver porcine tissue. The distribution of attached cells was more uniform with the magentic cell delivery approach compared with methodology used to date in the transplantation of bioengineered constructs in humans. In addition to airway and gastrointestinal tissue, this approach could be applied to a variety of hollow organs, e.g. bladder, larynx, and large blood vessels where there is a need to efficiently attach cells to non-flat surfaces.