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15 - General Engineering

University College London

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Article title

Nanoparticles functionalized with recombinant single chain Fv antibody fragments (scFv) for the magnetic resonance imaging of cancer cells.

Type

D - Journal article

DOI

10.1016/j.biomaterials.2009.10.036

Title of journal

Biomaterials

Article number

Volume number

Issue number

First page of article

1307

ISSN of journal

1878-5905

Year of publication

2010

URL

Number of additional authors

Additional information

This was the first paper published describing the functionalisation – via bioengineered hydrogen-bond linkers that successfully retained the receptor-seeking antibody presentation – of magnetic nanoparticles for targeting cancer cells in the human body. This was a key enabling step toward an embodiment of my vision of a combined diagnostic (through MRI) and therapeutic (through magnetic hyperthermia) approach to cancer treatment. It formed the basis of a £4.9M EU project, now under way, that has as its primary goal to reach clinical trials in the thermal treatment of glioblastoma (an aggressive form of brain cancer) by 2016

Interdisciplinary

Cross-referral requested

Research group

None

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract