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Acute and chronic exposure to shear stress have opposite effects on endothelial permeability to macromolecules.

This study showed that widely-used acute methods for shearing endothelial cells give results that are not relevant to the chronic shear occurring in vivo, and provided a novel explanation for the anti-atherosclerotic effect of NO. Funded by BBSRC (bb/d522711/1, £215k, PI: Weinberg), it involved an international collaboration with KCL and Louisville University. The high-throughput chronic methods have been adopted by other groups (e.g. Sheffield University); used in 3 further papers; and presented in an invited plenary at the 6th International Symposium on Biomechanics in Vascular Biology and Disease, Rotterdam, 2011. Follow-on funding has been obtained for two further PhD students.