Output details
15 - General Engineering
Imperial College London
Morphological evidence for a change in the pattern of aortic wall shear stress with age.
A major focus of cardiovascular biomechanics is the causal role played by fluid dynamic forces in atherosclerosis. For decades, the consensus has been that low wall shear stress triggers the disease. Our paper provides strong evidence that this consensus is wrong. The methods were developed in a collaboration with Georgia Tech, led by us (Am J Physiol Heart Circ Physiol. 2010;298:H536-H544). The heterodox conclusion led to the award of a £1.2M BHF Programme Grant (RG/11/5/28743, PI: Weinberg) investigating shear and atherosclerosis, and to an invited talk at the 2011 international Microscale Modeling in Biomechanics and Mechanobiology conference, Portugal.