Output details
15 - General Engineering
Imperial College London
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Article title
Modelling pulse wave propagation in the rabbit systemic circulation to assess the effects of altered nitric oxide synthesis.
Type
D - Journal article
Title of journal
Journal of Biomechanics
Article number
-
Volume number
42
Issue number
13
First page of article
2116
ISSN of journal
1873-2380
Year of publication
2009
URL
-
Number of additional authors
5
Additional information
Impaired arterial NO production is a major risk factor for cardiovascular disease but there are currently no simple, non-invasive methods for detecting it. We have proposed using the effect of NO on the peripheral pulse waveform to overcome this significant clinical problem. This study, initiated by a £335k BBSRC grant (E17208, PI: Weinberg), used a novel numerical model to elucidate how NO alters the waveform. It led to BHF funding (FS/09/030/27812, £274k) for Alastruey and Hunt in my group and then a KCL lectureship for Alastruey, and to an invited talk at the 6th World Congress of Biomechanics, Singapore, 2010.
Interdisciplinary
Yes
Cross-referral requested
-
Research group
None
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
