Output details
15 - General Engineering
Imperial College London
Noninvasive and localized neuronal delivery using short ultrasonic pulses and microbubbles.
Large molecule drugs are normally unable to cross the blood-brain barrier (BBB), preventing treatment of brain diseases. Here we showed that the BBB can be temporarily opened with mechanical stress created by ultrasonically-activated systemic microbubbles. Novel ultrasonic sequences minimised point stress, and safely improved dose and distribution. This is the first demonstration of the noninvasive and localised neuronal delivery of large molecules. It was highlighted in Nature Reviews Neurology (2011;7:597) and initiated international collaborative projects with neuroscientists (Prof. Götz, University of Queensland) and clinicians (Prof. Small, Columbia University).