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Controlling physiological angiogenesis by hypoxia-induced signaling.

This paper describes the phenomenon of hypoxia-induced signalling of dermal fibroblasts in plastically compressed collagen constructs. Signalling was quantified and an in vitro assay developed to test endothelial cell migration and aggregation to form capillary like structures. This concept of using hypoxia-induced signalling was also tested in vivo with simultaneous real-time O2 measurements. These findings establish the angiogenic potential of Hypoxia-Induced Signaling cells applicable to in vitro tissue modeling; implant vascularisation and engineering predictable angiogenic therapies. This has implications on developing tissue engineered implants that are capable of inducing and sustaining vascularisation that is an important requirement.