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Optimal synthesis of chromatographic trains for downstream protein processing.

In the biopharmaceutical sector, chromatography is the most widely used unit operation for protein purification, which is a major production cost. This paper addresses the need for systematic methodologies to design optimum downstream protein purification sequences from a number of alternative chromatographic steps at minimum cost while satisfying stringent purity requirements. Such decision tools can greatly facilitate the selection of new candidate drugs by early analysis and development of purification trains. This work was undertaken in collaboration with Biochem. Eng. (UCL), and culminated in a successful bid (EP/I033270/1) to establish the EPSRC Centre for Innovative Manufacturing in Emergent Macromolecular Therapies.