Output details
12 - Aeronautical, Mechanical, Chemical and Manufacturing Engineering
University College London
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Article title
Mimic of a Large-Scale Diafiltration Process by Using Ultra Scale-Down Rotating Disc Filter
Type
D - Journal article
DOI
Title of journal
BIOTECHNOL PROGR
Article number
-
Volume number
26
Issue number
2
First page of article
466
ISSN of journal
8756-7938
Year of publication
2010
URL
-
Number of additional authors
6
Additional information
An experimental and modelling ultra scale-down approach to mimic flux and transmission performance during diafiltration operations was established. This is based on a novel rotating disc filter device requiring only 1.5 ml of feed material. The method uses simple dead-end operation to mimic more complex crossflow operations used at larger scales and so overcomes the difficulty of accurately controlling pressure at such small scale. The work, which contributes to the USD Technologies impact case study, has led to further collaboration with Pfizer (Dr Sa Ho, sa.v.ho@pfizer.com).
Interdisciplinary
-
Cross-referral requested
-
Research group
None
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
