Output details
12 - Aeronautical, Mechanical, Chemical and Manufacturing Engineering
University College London
Principal Component Score Modelling for the Rapid Description of Chromatographic Separations.
This IMRC output provides a novel approach for the modelling of complex chromatographic separations that form the heart of biologics manufacture. Conventional mass-transfer models only accommodate a few components and require extensive experimental parameterisation. Using statistical models (Principal Component Analysis) we have shown, for the first time, how highly accurate correlations for complex separations can be made, accommodating critical scale-up parameters of direct industrial significance including bed dimensions and operating conditions. The generic technique, proven in industry with Fujifilm Diosynth, provides a rapid means for accurate scale up and process transfer with minimal consumption of resources (Dr John Liddell, j.liddell@fuijifilmdb.com).
