Output details
12 - Aeronautical, Mechanical, Chemical and Manufacturing Engineering
University College London
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Article title
Precipitation of filamentous bacteriophages for their selective recovery in primary purification.
Type
D - Journal article
DOI
Title of journal
Biotechnol Prog
Article number
-
Volume number
28
Issue number
1
First page of article
129
ISSN of journal
1520-6033
Year of publication
2012
URL
-
Number of additional authors
3
Additional information
The bottleneck in the efficient industrial application of filamentous phages is in the downstream processing of these viruses. This paper reports a novel approach to precipitation as an effective method for separating and purifying phages (with high yield and purity) from the main process contaminants including cell proteins and potentially cellular toxins. This work together with its companion paper (Branston et al, 2011, DOI 10.1002/bit.23066) has put UCL at the forefront of phage bioprocessing in the world. The work has led to a new collaboration with a US company Neurophage Pharmaceuticals (Dr Jason Wright, jwright@neurophage.com).
Interdisciplinary
-
Cross-referral requested
-
Research group
None
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
