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12 - Aeronautical, Mechanical, Chemical and Manufacturing Engineering

University College London

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Article title

Oxygen-controlled automated neural differentiation of mouse embryonic stem cells.

Type

D - Journal article

DOI

10.2217/rme.13.12

Title of journal

Regenerative Medicine

Article number

Volume number

Issue number

First page of article

171

ISSN of journal

1746-0751

Year of publication

2013

URL

Number of additional authors

Additional information

Current protocols for the directed differentiation of embryonic stem cells (ESC) tend to be inefficient and irreproducible. This innovative paper combines efficient oxygen controlled differentiation described in previous publications (Mondragon-Teran et al., 2009 and 2011 DOIs:10.1002/btpr.248 and 10.1002/btpr.675) with reproducible automation technology. We present a novel technology which controls the gaseous environment (O2, CO2 and temperature) during both the liquid handling and incubation stages of differentiation, meaning that cells are not repeatedly exposed to deleterious ambient conditions during lengthy cell culture protocols. The result is a significant step towards standardised and efficient processing of cells for human therapy.

Interdisciplinary

Cross-referral requested

Research group

None

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract