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12 - Aeronautical, Mechanical, Chemical and Manufacturing Engineering

University College London

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Article title

Microfabricated Modular Scale-Down Device for Regenerative Medicine Process Development

Type

D - Journal article

DOI

10.1371/journal.pone.0052246

Title of journal

PLOS ONE

Article number

e52246

Volume number

Issue number

First page of article

ISSN of journal

1932-6203

Year of publication

2012

URL

Number of additional authors

Additional information

This publication details how microfluidics can achieve a step change with the same impact in stem cell process development as microbioreactors delivered for traditional biotechnology. Feeder-attached human stem cell culture at a microfluidic scale was successfully demonstrated. The microfabricated device contains all the elements required to scout process conditions: cell growth substrates, extra-cellular matrices, seeding densities, culture medium exchange and perfusion rates can. An image-processing algorithm was developed which permits online quantification of colony sizes against the background of feeder cells. Based on this patented technology, an EPSRC Impact Acceleration Account (£100k) was won with Camtech Innovations Ltd.

Interdisciplinary

Cross-referral requested

Research group

None

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract