Output details

Microfluidic approaches for systems and synthetic biology.

This work describes how microfluidics can improve biological analysis and biocatalyst design. Consideration is given to biomolecule analyses which exploit high-throughput methods such as droplets travelling in channels, yet critically depend on channel coating methods, and coupling strategies with traditional analytical equipment (such as MS); to cell phenotype analyses with more complex (micro-)reactor design, necessitating in-situ instrumentation to demonstrate linkage with larger reactors. A first illustration is given as to the suitability of these different devices and fabrication methods to create a cellular assembly train, which could lead to de novo constructed cells (synthetic biology), e.g. for novel biocatalyst engineering.