Output details

The dual-state theory of prefrontal cortex dopamine function with relevance to catechol-o-methyltransferase genotypes and schizophrenia.

<24> This highly cited article summarizes and further advances a computational theory of dopamine function in prefrontal cortex. This theory, originally sparked by experimental and computational work of Durstewitz and Seamans in 1999-2001, has become one of the most influential in its field, cited hundreds of times, and has triggered a large number of experimental studies. This article extends the theory along several lines, expanding it deeper into the psychiatric domain. It is already highly cited and was one of the bases from the Mannheim-Heidelberg Bernstein Center for Computational Neuroscience’s €10Million grant funded by BMBF.