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Quantification of restitution dispersion from the dynamic changes of the T-wave peak to end, measured at the surface ECG.

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Increased spatial heterogeneity of ventricular rate dependent properties has been suggested as a precursor of fatal arrhythmias. This paper proposes for the first time a novel methodology to non-invasively measure this index from the body-surface electrocardiogram assessing this quantification with a combination of signal processing and computational modelling. The Telemetric and Holter ECG Warehouse initiative, an organization supported by the National Heart, Lung and Blood Institute and the Food and Drug Administration, has highlighted this approach as being a potential index to improve risk stratification. Recently, this index has been proposed as an independent predictor of sudden cardiac death.