Output details
11 - Computer Science and Informatics
University of Edinburgh
Evolutionary expansion and anatomical specialization of synapse proteome complexity
<28> Originality: Proteins at neuronal synapses underpin information processing in the brains of animals. This work describes the first evolutionary examination of synapse proteomes.
Significance: To date this remains the largest scale evolutionary systems biology analysis of neuronal synapse proteomes. It also presents the first data on invertebrate neuronal proteomes and the first correlation between evolutionary origin and spatial organisation of the mammal brain.
Rigour: Detailed bioinformatic analysis of over 700 neural proteins and their orthologues spanning 13 species was correlated with gene and protein expression data from four independent biological sources. Included primary invertebrate proteomics data as validation.
