Output details
15 - General Engineering
Keele University
Article title
Decreased osteogenesis, increased cell senescence and elevated Dickkopf-1 secretion in human fracture non union stromal cells.
Type
D - Journal article
Title of journal
Bone
Article number
-
Volume number
45
Issue number
4
First page of article
726
ISSN of journal
1873-2763
Year of publication
2009
Number of additional authors
4
Additional information
This paper describes experimental studies which characterise for the first time the cellular pathology of non-union fracture in humans. The findings from this study have contributed to two ‘first in human’ clinical trials in the UK for the treatment of non-union fracture and cartilage repair with mesenchymal stem cells. These trials are supported by several large grants (European Union ‘MyJoint’ grant, Arthritis Research UK Programme grant 18480 and Tissue Engineering Centre of Excellence grant 19429) and will undoubtedly influence future clinical practice for the treatment of these orthopaedic pathologies.
Interdisciplinary
-
Cross-referral requested
-
Research group
None
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
