Output details
15 - General Engineering
Keele University
Article title
A mathematical model of cartilage regeneration after cell therapy.
Type
D - Journal article
Title of journal
J Theor Biol
Article number
-
Volume number
289
Issue number
-
First page of article
136
ISSN of journal
1095-8541
Year of publication
2011
URL
-
Number of additional authors
3
Additional information
This EPSRC-funded study had two important clinical impacts. Firstly, it shows that the number of implanted cells hardly affects the quality of repair. This strengthened our case for allowing a wide range of implanted cell numbers in our chondrocyte and marrow stromal cell MIAIMP (Manufacturer's Authorisation for Investigational Medicinal Products) no. 21276 from the MHRA and in our clinical trial of marrow stromal cells and chondrocytes (EudraCT no. 2010-022072-31). Secondly, it shows a negligible difference in time between repair by implanted chondrocytes and marrow stromal cells. This strengthened the case for equal follow-up times of the arms in the trial.
Interdisciplinary
Yes
Cross-referral requested
-
Research group
None
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
