Output details

An assessment of the use of ultrasound in the particle engineering of micrometer-scale adipic acid crystals

Improved control of crystal product form is important to the manufacture of fine chemicals and pharmaceuticals. As part of our industrial CASE Award project with Pfizer, product particle characteristics of adipic acid obtained in a continuous crystallization process operated under continuous insonation were compared with the products of conventional dry milling techniques. Continuous insonation was found to be effective in producing highly reproducible particles comparable in size with micronization but with increased and more regular surface roughness of potential benefit to pharmaceutical manufacturing. This work led directly to £1M industrial collaboration with GSK and Pfizer sponsored by EPSRC (EP/I031480/1).