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11 - Computer Science and Informatics

University of East Anglia

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Output 4 of 70 in the submission

Article title

A method for the analysis of domain movements in large biomolecular complexes

Type

D - Journal article

DOI

10.1002/prot.22339

Title of journal

Proteins: Structure, Function, and Bioinformatics

Article number

Volume number

Issue number

First page of article

201

ISSN of journal

10970134

Year of publication

2009

URL

Number of additional authors

Additional information

<28> We present DynDom3D, a method for determining domains and hinge axes given two structures of a biomolecule. It is part of the DynDom package, the foremost software for studying protein domain movements (see http://www.cmp.uea.ac.uk/dyndom/ and http://www.ccp4.ac.uk/) with the DynDom website and server receiving 700-800 visits per month. Here a significant advance in methodology is described which enables DynDom to be applied to any biomolecular complex. It is particularly suited for determining the presence of an allosteric mechanism. DynDom3D is part of the SBGrid Consortium software library at Harvard Medical School (see http://sbgrid.org).

Interdisciplinary

Yes

Cross-referral requested

Research group

None

Citation count

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract