Output details

Combining G-quadruplex targeting motifs on a single peptide nucleic acid scaffold: a hybrid (3+1) PNA-DNA bimolecular quadruplex.

It has been a major goal within biological science to achieve controlled intervention and manipulation of cellular events by strategies that target nucleic acids and alter gene expression. This article describes a novel therapeutic approach using Peptide Nucleic Acids to regulate the expression of disease-associated genes by targeting G-quadruplex structures in untranslated regions of the genome. I was awarded a 4-year European (FP7) Marie-Curie Career Integration grant for a research project extending this proof-of-concept study (CIG 293981, £80k, Sept 2011-Aug 2015).