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Manufacture of small calibre quadruple lamina vascular bypass grafts using a novel automated extrusion-phase-inversion method and nanocomposite polymer.

This paper reports on the fabrication of arterial grafts from a chemically and mechanically biocompatible nano-structured composite (UCL-NANO). This material was originally pioneered and patented by UCL/Royal Free Hospital. This paper has focused on the critical requirements of appropriate elastic behaviour and long term resistance to biodegradation. Crucially, it was shown that the material composition and method of manufacture were critical to producing ideal mechanical properties for clinical applications. This nano-structures composite is now finding wider applications in body prosthetics including trachea implants.