Output details

Understanding the limits to generalizability of experimental evolutionary models

The author made a substantial contribution to the conception and design of the study, the organisation of the conduct of the study, to carrying out the study (including acquisition of study data) and to analysis and interpretation of study data. The author helped draft the output and critiqued the output for important intellectual content. This research took 4 person years. RB developed models, wrote simulation codes (bespoke pseudo arc-length equilibrium solvers) and proved theorems on the dynamical systems defining bacteria-phage coevolution (model reduction and perturbation theory for dissipative systems). This categorized dynamics in any model system (including this experiment) into two classes. Key to the main result, mathematics was summarised in the supplementary (without proof – http://goo.gl/qg5PtA ). RB calibrated models and collaborated with IG to extend prior gene-for-gene infection genetics to this experiment. RB analysed data and proposed the successful power-law infection model. IG, RB and LH wrote manuscript, IG and RB wrote supplementary.