Output details

Understanding the limits to generalizability of experimental evolutionary models

The author made a substantial contribution to the conception and design of the study, the organisation of the conduct of the study, to carrying out the study (including acquisition of study data) and to analysis and interpretation of study data. The author helped draft the output and critiqued the output for important intellectual content. This research took 4 person years. IG designed the study, first using abstract mathematical model classes (PDEs) not tailored to experiments. IG then developed system-specific models by abstracting phage-bacteria adsorption, calibrated using parameter values from the literature and from bespoke experiments. Authors IG and RB (alone) collaborated on extending prior gene-for-gene (G4G) infection genetics models to this experiment, showing neither G4G nor ‘matching alleles’ were appropriate, contrary to prior literature. IG analysed and interpreted experimental data (conducted by Forde), suggesting changes to subsequent experiments. IG, RB and LH wrote the manuscript, IG and RB wrote the supplementary.