Output details
11 - Computer Science and Informatics
University of Edinburgh
Abstract Interpretation of Cellular Signalling Networks
<28> Originality: This paper proposes a method to solve reachability questions in rule-based models.
Significance: This paper shows that substantial models verify a stated syntactic condition (up to suitable transformations). It illustrates on a sizeable example a method to explore the set of complexes that can be generated from a rule-based model. This is useful to debug realistic large-scale rule-based models.
Rigour: Solving reachability questions is done via the construction of a finite abstract interpretation which yields a tractable superset of reachable states. A simple criterion for this superset to be exact is given, as well as sufficient syntactic conditions.