Output details

A computational framework for fluid-solid-growth modeling in cardiovascular simulations

We introduced a “Fluid-Solid-Growth” framework to describe the stress-mediated growth & remodeling seen in blood vessels, combining Constrained Mixture Theory ideas with efficient methods for subject-specific 3D Fluid-Structure Interactions. An iterative coupling between growth & remodeling time-scales (i.e., months) and hemodynamics scales (i.e., seconds) is introduced for the first time. A thorough description of the kinetics, nonlinear solid and fluid mechanics is provided. This establishes the framework for a fast-growing field that has the potential to understand and describe the mechanobiology of development of arterial disease.