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Cerebral formation of free radicals during hypoxia does not cause structural damage and is associated with a reduction in mitochondrial PO2; evidence of O2-sensing in humans?

International collaboration led by Bailey and first ever human study to demonstrate that free radical output by the brain during hypoxia is an adaptive response underlying oxygen sensing. Led to invited plenary talks at international conferences (International Symposium on High-Altitude Tolerance, Heidelberg, Germany, 2013; Canadian Society for Exercise Physiology, Regina, Canada 2012; American College of Sports Medicine, San Fransisco, USA, 2012; Oxygen, Davos, Switzerland, 2011). Paper cited in a state-of-the-art review by one of the World’s foremost authrorities [Scherrer, U. et al. (2012). Current Respiratory Medicine Reviews 8: 123-130] and considered a “Must Read” by F1000Prime (Highlighted Paper).