Output details
13 - Electrical and Electronic Engineering, Metallurgy and Materials
Queen Mary University of London : B - Materials
High-affinity glycopolymer binding to human DC-SIGN and disruption of DC-SIGN interactions with HIV envelope glycoprotein.
We have demonstrated for the first time the interaction between dendritic cell lectin (DC-SIGN) and synthetic glycopolymers using surface plasmon resonance spectroscopy. Mannosylated glycopolymers can be used to inhibit HIV glycoprotein binding to DC-SIGN, which block one of the main pathways of HIV entry into immune system. This approach has been extended to other glycopolymer architectures and our current results are very exciting because certain architectures can provide higher affinity than natural glycoprotein. This approach can be used to reduce the impact of infectious diseases.