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13 - Electrical and Electronic Engineering, Metallurgy and Materials

University of Cambridge

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Article title

Collagen–hyaluronic acid scaffolds for adipose tissue engineering

Type

D - Journal article

DOI

10.1016/j.actbio.2010.05.005

Title of journal

Acta Biomaterialia

Article number

Volume number

Issue number

First page of article

3957

ISSN of journal

17427061

Year of publication

2010

URL

http://www.ncbi.nlm.nih.gov/pubmed/20466086

Number of additional authors

Additional information

This paper established the principle of generating artificial mammary glands in-vitro. Follow-up work demonstrates this with mouse cell-lines (PLOSOne2011;6:e25661) leading to CRUK collaborations to culture human cell-lines from reduction mammoplasties in the optimized scaffolds. Replacing in-vivo studies with an in-vitro humanized model would substantially reduce the use of animals in breast-cancer research and could be used in personalized treatments for breast cancer through tailored assays of biopsies. Cameron has secured follow-up funds from a €2.5M ERC Advanced Grant, and the Daphne Jackson and Isaac Newton Trusts. The work was featured on Radio 4’s “Leading Edge” programme.

Interdisciplinary

Cross-referral requested

Research group

None

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract