Output details
15 - General Engineering
Keele University
Delivery of short interfering ribonucleic acid-complexed magnetic nanoparticles in an oscillating field occurs via caveolae-mediated endocytosis.
Nanomagnetic gene transfection was first demonstrated by our group at the University of Florida in 1999. This paper is the first to elucidate mechanisms by which particle/DNA complexes are internalized in oscillating and static nanomagnetic gene transfection. The oscillating technique has several advantages over other non-viral transfection methods, including rapid transfection time, high cell viability, and enhanced gene expression and transfection efficiency. I hold two patents on this technology (with others pending) and it forms the basis of a successful spin-off company, nanoTherics (www.nanotherics.com). This work was funded by CFGT Consortium, MRC Milstein Award (G0701054), BBSRC (BB/C506172).