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Patterned growth of neuronal cells on modified diamond-like carbon substrates

Paper describes pioneering research across three faculties and Bristol Eye Hospital into interaction of Diamond-Like Carbon (DLC) with mammalian neuronal cells. Work investigates ability of various forms of DLC to support growth and survival of primary central-nervous-system neurones and neuroblastoma cells. Ultimately phosphorous-doped DLC is used to culture cortical neurones in predetermined micro-patterns. Cell activity is recorded using novel ultra-low current-sensing techniques (developed by Biochip Group through Micron Corporation). Work raises potential of DLC as bio-material for central nervous system implantation and research has extensive potential ramifications for spatially-controlled tissue engineering in areas such as retina and heart-muscle/electronic pacer implants.