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Revisiting the ultra-high dose rate effect: implications for charged particle radiotherapy using protons and light ions.

There is increasing interest in developing practical means of delivering accurate, targeted radiotherapy treatments using ionizing particles (carbon ions, protons) rather than photons. The work presented in this publication points to more appropriate radiotherapy treatment planning techniques to be applied in cancer therapy facilities currently in development in the United Kingdom (http://www.cancerresearchuk.org/cancer-info/news/archive/cancernews/2013-08-01-Manchester-and-London-proton-beam-therapy-units-confirmed) and in other countries (Uni-Heidelberg) .This publication is an output from collaborative work with the Oxford University Physics Department, the Science and Technology Facilities Council’s (STFC) Daresbury Laboratory, and the interdisciplinary Oxford Martin School, and was supported by an EPSRC UK Basic Technology Grant (EP/E032669/1).