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Nano-zinc oxide damages spatial cognition capability via over-enhanced long-term potentiation in hippocampus of Wistar rats

-RAEng funded investigation into nano-particle toxicity.

-Influence of particle dosage level in suspension is shown to be the most important effect on the safety-toxicity threshold and that none toxicity level of ZnO suspension is identified below 0.05wt% in suspension.

-Nano CuO, Ag, CNTs, TiO2, WC, etc., show similar impact level of nano-toxicity at 0.05wt.% threshold on the CNS.

-Research has brought major concept changes in the nano toxicity field, which will influence policy and practical regulations on the use of functional nano particles across healthcare, medical research and industry, where the nano toxicity has been inhibiting the applications of nano-materials.