Output details
12 - Aeronautical, Mechanical, Chemical and Manufacturing Engineering
University College London
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Article title
A methodology for global-sensitivity analysis of time-dependent outputs in systems biology modelling
Type
D - Journal article
Title of journal
Journal of The Royal Society Interface
Article number
-
Volume number
9
Issue number
74
First page of article
2156
ISSN of journal
1742-5689
Year of publication
2012
URL
-
Number of additional authors
2
Additional information
This sophisticated methodology (only very recently published) will be key for exploring sensitivity and accuracy in complex physiological models to build towards use of complex quantitative phenomenological models in medicine. The method will be used to identify weaknesses that require more accurate data necessary if they are to be used in a clinical setting. The paper has inspired further work with clinical colleagues (in liver disease) identifying more accurate parameter values with a view to their use in diagnosis of liver disease.
Interdisciplinary
-
Cross-referral requested
-
Research group
None
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-