Output details
15 - General Engineering
Imperial College London
Article title
Clustering of alpha(5)beta(1) integrins determines adhesion strength whereas alpha(v)beta(3) and talin enable mechanotransduction.
Type
D - Journal article
Title of journal
Proceedings of the National Academy of Sciences of the United States of America
Article number
-
Volume number
106
Issue number
38
First page of article
16245
ISSN of journal
1091-6490
Year of publication
2009
URL
-
Number of additional authors
3
Additional information
This work elucidated the cellular roles of the major proteins that orchestrate mechanotransduction. We found that α5β1 integrin regulates cellular adhesion, while αvβ3 integrin and talin are engaged in connecting the adhesion site to the cytoskeleton and in responding to external mechanical stimuli; we thus demonstrated exclusive and complementary functions for these mechanotransducers. The work contributed to obtaining one excellence award (Spanish Ramon y Cajal award 2010/ €225k), and to securing research funding (Spanish Grant for Basic Science 2011/ €150k).
Interdisciplinary
Yes
Cross-referral requested
-
Research group
None
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
