Output details
13 - Electrical and Electronic Engineering, Metallurgy and Materials
University of Southampton
On-chip epithelial barrier function assays using electrical impedance spectroscopy
Significance of output:
This paper describes a microfluidic platform for ex-vivo tissue engineering, where cells harvested from human airways are culture in a micro-chip. The final tissue construct is identical to human lung tissue and enables complex analysis of the effect of allergens, viruses and drugs without human or animal experimentation. This initial work led to a new grant (NC3R G1001598) to further the understanding of the human airways and for research into treatment of allergy and asthma. We are currently in discussion with GSK to develop the technology to investigate and improve aerosol drug delivery into the lung.