Output details
12 - Aeronautical, Mechanical, Chemical and Manufacturing Engineering
University of Birmingham : B - Chemical Engineering
Article title
Application of external lubrication during the roller compaction of adhesive pharmaceutical formulations
Type
D - Journal article
Title of journal
Pharmaceutical Development and Technology
Article number
-
Volume number
18
Issue number
1
First page of article
246
ISSN of journal
1083-7450
Year of publication
2013
URL
-
Number of additional authors
5
Additional information
Magnesium Stearate (Mg St) is used as a lubricant in tablet formulations to help get material through the process. However Mg St has a significant detrimental effect on tablet performance in-vivo and so minimising Mg St content is desirable. By spraying the Mg St only onto the surface that required lubrication, a significant reduction (100 fold) can be achieved while maintaining throughput levels. The work was funded in part by EPSRC (through EngD scheme) and Bristol Myers Squib who collaborated on the project. Further work is ongoing in optimisation of the spray system and full process chain.
Interdisciplinary
-
Cross-referral requested
-
Research group
A - Food, Health and Nutrition
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
