Output details

Both superficial and deep zone articular chondrocyte subpopulations exhibit the Crabtree effect but have different basal oxygen consumption rates.

This paper is one of a series investigating alterations in the energy metabolism of chondrocytes and provides accurate quantitative data on oxygen consumption of different subpopulations of chondrocytes under normoxic and hypoxic conditions. The study was shortlisted for the prestigious New Investigator Recognition Award of the Orthopaedic Research Society (50 shortlisted from approx. 3000 papers). The paper has significant importance for those studying chondrocyte physiology, and in particular researchers using modeling methods to assess spatial gradients of oxygen in 3-D. This is critical importance to the development of new cartilage for repair strategies based on tissue engineering and regenerative medicine.