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Output details

15 - General Engineering

University of Southampton

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Output 274 of 706 in the submission

Article title

Experimental–computational evaluation of human bone marrow stromal cell spreading on trabecular bone structures

Type

D - Journal article

DOI

10.1007/s10439-009-9676-3

Title of journal

Annals of Biomedical Engineering

Article number

Volume number

Issue number

First page of article

1165

ISSN of journal

0090-6964

Year of publication

2009

URL

http://www.ncbi.nlm.nih.gov/sites/entrez/19296221

Number of additional authors

Additional information

Significance of output:

Over 2 million bone grafting procedures are carried out per year worldwide to treat severe trauma, fracture non-unions, bone tumours, spinal fusions and failed hip and knee replacements. However, implant failure is multifactorial and ill understood. This paper represents the application of an interdisciplinary systematic engineering approach, together with Medicine, using specifically designed experiments to quantify the impact of porous structure on cell growth and translate this into predictive computational models for biomaterial optimization.

Interdisciplinary

Cross-referral requested

Research group

None

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract