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Output details

26 - Sport and Exercise Sciences, Leisure and Tourism

University of South Wales

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Output 32 of 33 in the submission

Article title

Transcerebral Exchange Kinetics of Nitrite and Calcitonin Gene-Related Peptide in Acute Mountain Sickness: Evidence Against Trigeminovascular Activation?

Type

D - Journal article

DOI

10.1161/STROKEAHA.108.543959

Title of journal

Stroke

Article number

Volume number

Issue number

First page of article

2205

ISSN of journal

1524-4628

Year of publication

2009

URL

Number of additional authors

Additional information

International collaboration led by Bailey, funded by The Danish National Research Council including funding for Dr KA Evans as a post-doctoral researcher. First ever human study to demonstrate that the human brain loses nitric oxide during hypoxia (including first rate of exchange calculation) and despite widespread speculation, it does not release the headache molecule, calcitonin gene-related peptide (CGRP), thereby excluding its role in the pathophysiology of acute mountain sickness arguing against the clinical use of CGRP receptor antagonism.

Interdisciplinary

Cross-referral requested

Research group

1 - Vascular Health

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract