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15 - General Engineering

Keele University

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Output 71 of 127 in the submission

Article title

Magnetic nanoparticles as gene delivery agents: enhanced transfection in the presence of oscillating magnet arrays.

Type

D - Journal article

DOI

10.1088/0957-4484/19/40/405102

Title of journal

Nanotechnology

Article number

Volume number

Issue number

First page of article

405102

ISSN of journal

0957-4484

Year of publication

2008

URL

http://www.ncbi.nlm.nih.gov/pubmed/21832609

Number of additional authors

Additional information

This is the first paper to introduce nanomangetic gene transfection based on oscillating magnet arrays. This technology was developed in collaboration with The University of Florida and is the foundation for a successful spin-of company, nanoTherics. The paper describes work on gene transfection of human lung epithelial cells (the technology is being developed as a potential gene delivery vehicle for treating Cystic Fibrosis). Protein expression was increased by more than five-fold compared to static nanomagnetic transfection and market-leading cationic lipid reagents, with no impact on cell viability. This work was funded by CFGT Consortium, MRC Milstein Award (G0701054), BBSRC (BB/C506172).

Interdisciplinary

Cross-referral requested

Research group

None

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract