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Output details

13 - Electrical and Electronic Engineering, Metallurgy and Materials

University of Strathclyde

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Output 14 of 236 in the submission

Article title

A systematic survey of the response of a model NF-κBκB signalling pathway to TNFαTNFα stimulation

Type

D - Journal article

DOI

10.1016/j.jtbi.2011.12.014

Title of journal

Journal of Theoretical Biology

Article number

Volume number

297

Issue number

First page of article

137

ISSN of journal

0022-5193

Year of publication

2012

URL

Number of additional authors

Additional information

This research integrates modelling, systems analysis and experimental techniques to explore oscillatory phenomena in NF-kB signal pathway, which is pivotal in controlling innate immunity, but can also contribute to carcinogenesis. For the first time sustained oscillation in this pathway was investigated using bifurcation theory together with experimental evidence. It brought new insights and inspired a number of further experimental efforts (Prof. White’s lab at Manchester University, mike.white@manchester.ac.uk; Prof. Hoffmann’s lab, University of California, San Diego, ahoffman@ucsd.edu).

Interdisciplinary

Cross-referral requested

Research group

E - Institute for Energy and Environment (InstEE)

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract