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The effect of adherens junction components on keratinocyte adhesion in vitro: Potential implications for sealing the skin-implant interface of intraosseous transcutaneous amputation prostheses.

Engineering materials and coatings to encourage the formation of an infection-free seal around skin-penetrating devices could provide a solution for countless clinical problems, ranging from amputation prosthetics to long-term tracheotomy devices. Keratinocytes; the surface layer skin cells, provide the bodies first line of defence against infection. This manuscript investigates a novel coating strategy to enhance their attachment to implant materials for skin-penetrating amputation prosthetics. If the coating strategy is successful and enters clinical trials, it could potential provide the first successful means of preventing keratinocytes from migrating around skin-penetrating devices and leading to implant failure due to infection.