Output details
15 - General Engineering
University College London
The osteoinductivity of silicate-substituted calcium phosphate.
The work, in an ovine model, showed the use of a silicon containing bone graft substitute resulted in significantly increased amounts of bone (7-fold increase) within and in direct contact (12-fold increase) with the scaffold compared to non-silicon containing material. This work is of high importance as it too has led to the development of graft substitute materials developed with and marketed by Baxter Healthcare. This work showed the significant effect of adding silicate ions to the lattice of a hydroxyapatite scaffold. Silicate-substituted hydroxyapatite bone graft substitute materials are now used clinically and mainly in spinal fusion surgery.