Output details

Raman spectroscopy reveals differences in collagen secondary structure which relate to the levels of mineralisation in bones that have evolved for different functions

The material properties of the matrix of bone are related to both its organic and inorganic phases. Bone volume mineral fraction relates to the material modulus. Changes in matrix composition are found in several metabolic, genetic and age related bone diseases. This paper explores the hypothesis that a minimally invasive/destructive technique of Raman spectroscopy can determine the composite composition and associated modulus. The subtle changes shown in collagen spectral signature associated with very different mineral levels in specific bones will identify mechanisms controlling mineralisation, contributing to new therapeutic targets to treat devastating chronic bone diseases.