Output details
15 - General Engineering
King's College London
Article title
Therapeutic target metabolism observed using hyperpolarized 15N choline
Type
D - Journal article
Title of journal
Journal of the American Chemical Society
Article number
-
Volume number
130
Issue number
14
First page of article
4598
ISSN of journal
0002-7863
Year of publication
2008
URL
-
Number of additional authors
5
Additional information
The first demonstration that choline, a biomarker for cancer detection, can be hyperpolarised and the signal of 15N-choline enhanced by at least 4 orders of magnitude allowing detection by MRI. This work led to hyperpolarisation of other clinically relevant compounds: 31P-choline kinase [NMR Biomed, 2009], 13C for carboxypeptidase [Magn. Res. Med, 2009] and 13C/15N in gadolinium contrast agents [Contrast Media and Molecular Imaging, 2009]. The ability to hyperpolarise important metabolites with relaxation times in the order of minutes opens up an exciting new range of applications in medical imaging usually hindered by the intrinsic low sensitivity of MR.
Interdisciplinary
-
Cross-referral requested
-
Research group
None
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
